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Related Experiment Videos

Regional functional depression immediately after ventricular septal defect closure.

T Alexander Quinn1, Santos E Cabreriza, Brianne F Blumenthal

  • 1Department of Biomedical Engineering, Columbia University, New York, New York, USA.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|September 29, 2004
PubMed
Summary

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Immediately after ventricular septal defect (VSD) repair, left ventricular ejection is depressed. This functional depression stems from localized impairment of septal mechanics, not preload or afterload changes.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Echocardiography

Background:

  • Left ventricular ejection is often depressed post-ventricular septal defect (VSD) repair.
  • Potential causes include reduced preload, closure of a low-impedance path, patch stiffness, or surgical trauma.

Purpose of the Study:

  • To investigate the mechanisms behind acute functional depression after VSD repair.
  • To differentiate between global and localized changes in left ventricular function.

Main Methods:

  • Segmental wall-motion analysis using intraoperative echocardiograms.
  • Comparison of patients undergoing VSD repair versus atrial septal defect (ASD) repair.

Main Results:

  • VSD repair led to asymmetric changes in left ventricular end-systolic segment length and localized fractional shortening decrease in septal and lateral walls.

Related Experiment Videos

  • ASD repair resulted in symmetric increases in fractional shortening.

    • Conclusions:

    • Acute functional depression after VSD repair is primarily due to localized impairment of septal function.
    • Findings suggest septal mechanics are critically affected by VSD closure.