Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Axon mediated interneuron migration.

Matthew F McManus1, Ilya M Nasrallah, Pallavi P Gopal

  • 1University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Journal of Neuropathology and Experimental Neurology
|September 30, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vulnerability of anterior medial temporal lobe subregions to early tau-related neurodegeneration in Alzheimer's disease: Converging evidence from tau-PET and plasma p-tau217.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Alzheimer's disease neuropathology plasma biomarkers and cognition in midlife: a community-based cohort study.

Lancet (London, England)·2026
Same author

Uncovering distinct spatiotemporal trajectories of T-N mismatch subtypes with likely co-pathology in Alzheimer's disease using event-based modeling.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Medial temporal lobe Tau-Neurodegeneration mismatch from structural imaging and plasma biomarkers.

Brain : a journal of neurology·2026
Same author

Coupled cross-sectional and longitudinal non-negative matrix factorization reveals dominant brain aging trajectories in 48,949 individuals.

Nature communications·2026
Same author

Hippocampal Volume and Brain Tau Pathology in Opioid Use Disorder: Associations with Non-Fatal Opioid Overdose.

Addiction neuroscience·2026
Same journal

An unusual extra-axial supratentorial presentation of atypical teratoid/rhabdoid tumor in a child.

Journal of neuropathology and experimental neurology·2026
Same journal

Primary intracranial sarcoma, DICER1-mutant: 5 cases highlighting variable clinical and molecular features.

Journal of neuropathology and experimental neurology·2026
Same journal

Novel YWHAE-NTRK3 fusion in a pediatric glioma.

Journal of neuropathology and experimental neurology·2026
Same journal

Comprehensive clinicomolecular characterization of a methylation-defined supratentorial high-grade astrocytoma with piloid features in a young adult with confirmed germline NF1 mutation.

Journal of neuropathology and experimental neurology·2026
Same journal

Spatial mapping, isolation, and culture of primary human microglia and astrocytes: A systematic review and framework for glial cell-based models.

Journal of neuropathology and experimental neurology·2026
Same journal

Multiparameter flow cytometry of CSF identifies elevated CD8+ effector memory and TEMRA T-cells in immune-mediated neurologic disorders.

Journal of neuropathology and experimental neurology·2026
See all related articles

Mammalian forebrain development involves cell migration. This study shows that inhibitory interneurons migrate along axons, with distinct preferences based on cell age, providing insights into neural development and malformations.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Mammalian forebrain development relies on precise cell migration.
  • Defects in neuronal migration cause human neurological disorders.
  • Radial glia guide radial migration; axons are hypothesized to guide non-radial migration.

Purpose of the Study:

  • To directly test if axons support non-radial cell migration.
  • To investigate the role of axons in the migration of inhibitory interneurons.
  • To identify age-dependent substrate preferences for interneuron migration.

Main Methods:

  • Colocalization studies of GABAergic cells with specific axonal markers (TAG-1, neurofilaments).
  • Development of an in vitro assay to observe cell migration on axons.

Related Experiment Videos

  • Analysis of migration patterns of early-born versus later-born interneurons on different axonal substrates.

    • Main Results:

    • Early born GABAergic cells associate with TAG-1+ axons; later born cells associate with neurofilament-positive/TAG-1- processes.
    • In vitro assay demonstrates preferential migration of early interneurons on TAG-1+ axons.
    • Later born interneurons exclusively migrate on neurofilament-positive/TAG-1- processes, showing age-dependent substrate specificity.

    Conclusions:

    • Provides the first direct evidence that ganglionic eminence cells migrate on axons.
    • Demonstrates age-dependent substrate preference in axonophilic cell migration.
    • The developed in vitro assay is a valuable tool for studying molecular cues in neural development.