Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Bioavailability of hydroxychloroquine tablets assessed with deconvolution techniques.

S E Tett¹, D J Cutler, R O Day

¹Department of Pharmacy, University of Sydney, NSW, Australia.

Journal of Pharmaceutical Sciences

|February 1, 1992

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Identifying the association between tacrolimus exposure and toxicity in heart and lung transplant recipients: A systematic review.

Transplantation reviews (Orlando, Fla.)·2021

Same author

Trends, determinants and differences in antibiotic use in 68 residential aged care homes in Australia, 2014-2017: a longitudinal analysis of electronic health record data.

BMC health services research·2020

Same author

Towards precision dosing of vancomycin in critically ill patients: an evaluation of the predictive performance of pharmacometric models in ICU patients.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020

Same author

Towards precision dosing of vancomycin: a systematic evaluation of pharmacometric models for Bayesian forecasting.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019

Same author

Evaluation of Clinical Relevance of Drug-Drug Interaction Alerts Prior to Implementation.

Applied clinical informatics·2018

Same author

Interrogation of a longitudinal, national pharmacy claims dataset to explore factors that predict the need for add-on therapy in older and socioeconomically disadvantaged Australians with type 2 diabetes mellitus patients (T2DM).

European journal of clinical pharmacology·2018

Four deconvolution methods accurately assessed hydroxychloroquine bioavailability in healthy volunteers. These validated techniques offer a faster, more efficient way to determine drug absorption in patients.

Area of Science:

Pharmacokinetics
Drug Absorption Studies

Background:

Hydroxychloroquine bioavailability is crucial for therapeutic efficacy.
Conventional bioavailability studies are time-consuming.

Purpose of the Study:

To evaluate four deconvolution methods for assessing hydroxychloroquine absolute bioavailability.
To compare the efficiency of deconvolution methods with conventional techniques.

Main Methods:

Four deconvolution methods were applied: staircase, delta function, and least squares (single and sequential).
Nine healthy volunteers received oral hydroxychloroquine tablets and intravenous infusions in a crossover design.
Absolute bioavailability was calculated using the deconvolution techniques.

Main Results:

Related Experiment Videos

The four deconvolution methods yielded statistically similar results for hydroxychloroquine absorption.
The mean fraction of hydroxychloroquine absorbed was 0.67 +/- 0.12.
Absorption half-life was 4.0 +/- 1.3 h, with a lag time of 0.57 +/- 0.30 h.

Conclusions:

Deconvolution methods provide a validated and efficient approach to assess hydroxychloroquine bioavailability.
These methods significantly reduce study duration compared to conventional AUC ratio methods.
Accurate bioavailability assessment is vital for preventing therapeutic failure due to low or variable drug absorption.