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Updated: Aug 21, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
The use of gene therapy in cancer research and treatment
E T Shinohara1, B Lu, D E Hallahan
1Department of Radiation Oncology, Vanderbilt University, 1301 22nd Avenue South, B-902, The Vanderbilt Clinic, Nashville, Tennessee 37232-5671, USA.
Abstract:
Gene therapy involves identifying a gene of interest and then manipulating the expression of this gene through a variety of techniques. Here we specifically address gene therapy's role in cancer research. This paper will encompass thoroughly investigated techniques such as cancer vaccines and suicide gene therapy and the latest advancements in and applications of these techniques. It will also cover newer techniques such as Antisense Oligonucleotides and small interfering RNAs and how these technologies are being developed and used. The use of gene therapy continues to expand in cancer research and has an integral role in the advancement of cancer treatment.
Insights
Gene therapy offers innovative cancer treatments by manipulating gene expression. This research explores established methods like cancer vaccines and suicide gene therapy, alongside emerging Antisense Oligonucleotides and small interfering RNAs for advanced cancer research.
Area of Science:
- Oncology
- Molecular Biology
- Biotechnology
Background:
- Gene therapy is a rapidly evolving field focused on modifying gene expression to treat diseases.
- Cancer research increasingly utilizes gene therapy to develop novel therapeutic strategies.
- Understanding gene therapy's diverse techniques is crucial for advancing cancer treatment.
Purpose of the Study:
- To provide a comprehensive overview of gene therapy applications in cancer research.
- To discuss established and emerging gene therapy techniques for cancer treatment.
- To highlight the expanding role and advancements of gene therapy in oncology.
Main Methods:
- Review of established gene therapy techniques including cancer vaccines and suicide gene therapy.
- Exploration of novel gene therapy approaches such as Antisense Oligonucleotides and small interfering RNAs.
- Analysis of current advancements and applications in gene therapy for cancer.
Main Results:
- Gene therapy encompasses a range of techniques for cancer treatment.
- Established methods like cancer vaccines and suicide gene therapy show significant promise.
- Emerging technologies like Antisense Oligonucleotides and small interfering RNAs are under active development.
Conclusions:
- Gene therapy plays an integral role in the advancement of cancer treatment.
- The continuous expansion of gene therapy techniques offers new hope for cancer patients.
- Further research and development in gene therapy are essential for future oncology breakthroughs.
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