Pathology of primary cutaneous B-cell lymphomas: diagnosis and classification

The skin is the second most common extranodal site for non-Hodgkin's lymphomas. Therefore, hematologists, pathologists, and dermatologists need to be familiar with these lymphomas. Primary cutaneous B-cell lymphomas are less common than T-cell lymphomas but have received much attention in the past few years. Their typical clinical and pathologic features are becoming clear. However, there is still some disagreement in terminology and characteristics of these lymphomas between the World Heath Organization (WHO) classification and the European Organisation for Research and Treatment of Cancer (EORTC) proposal for primary cutaneous lymphomas. This review will focus on the features of primary cutaneous B-cell lymphomas, compare and contrast areas of discordance between the WHO and EORTC systems, and outline areas for further investigation.