Use of allograft amniotic membrane for control of intra-abdominal adhesions

The authors have studied 60 rabbits to determine the effect and fate of allograft amniotic membranes (devoid of chorion) used in the intra-peritoneal cavity to control adhesions secondary to bowel perforation and bacterial contamination. The experimental animals revealed dramatic differences when compared to the control with major reduction in adhesions. Abscesses remained localized and contained. No untoward reactions were noted in the host. Violent immunologic rejection did not occur. The membranes gradually disintegrated and left little or no evidence of its presence. Important clinical applications are obvious.