Related Experiment Video
Updated: Aug 21, 2026
Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
[Effect of orthopedic premaxillary retrution on craniofacial development in animal model]
Tao Wang1, Da-zhang Wang, Hui-fen Xu
1Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Chongqing University of Medical Sciences, Chongqing 400015, China.
Objective:
To observe the whole process of cranio-maxillofacial development of an animal model with bilateral premaxillary clefts, after being exerted with premaxillary retro-pressing forces.
Methods:
Experimental rabbits with premaxillary clefts and without clefts were exerted with retro-pressing forces respectively. Roentgenographic cephalometric analysis and different investigations of premaxillary suture were performed during the whole craniofacial development.
Results:
The longitudinal cephalometric analysis showed that a temporary retarding effect of mid-facial growth existed. The hindrance of maxillary growth potentiality did not occur in spite of being exerted retro-pressing force as to this experimental extent.
Conclusions:
(1) Infant rabbit combined with the designed retro-pressing appliance is an ideal experimental model for quantitative study of active orthopedic treatment of protruding premaxilla. (2) Using active preoperative orthopedics to reposit the protruding premaxilla of bilateral cleft palate is a reasonable and effective approach.
