Related Experiment Video
Updated: May 13, 2026
17:03
Direct Observation of Enzymes Replicating DNA Using a Single-molecule DNA Stretching Assay
Published on: March 24, 2010
The power of pumping together; deconstructing the engine of a DNA replication machine
Brandt F Eichman1, Ellen Fanning
1Department of Biological Sciences and Center for Structural Biology, Vanderbilt University, 465 21st Avenue South, Nashville, TN 37232, USA.
Cell
|September 30, 2004
Abstract:
The replicative DNA helicase lies at the heart of the eukaryotic replication machine, yet how it works remains puzzling. New structures of the viral replicative helicase SV40 T antigen suggest that a novel concerted mode of nucleotide binding and hydrolysis powers conformation changes and DNA unwinding.
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