Related Experiment Video
Updated: Aug 21, 2026

Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology
Published on: March 27, 2018
[Central dopamine receptors: general considerations (Part 1)]
1EA1046, Laboratoire de Pharmacologie, Faculté de Médecine, Université de Lille 2, Lille.
Abstract:
Specific protein G-coupled receptors mediate the effects of dopamine in its projection areas. Five dopaminergic receptors have been cloned, characterized and classified in two families, the D1-like family (D1- and D5-receptor subtypes) and the D2-like family (D2-, D3- and D4-receptor subtypes). These five dopamine receptor subtypes are characterized by their diversity in terms of transduction, distribution, pharmacology, functions, and regulation, leading to pleiotropic pathophysiological and pharmacological involvements in neuropsychiatric disorders underlain by a deregulation of the dopaminergic system.
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