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Published on: July 13, 2014
Maternal coffee drinking in pregnancy and risk of small for gestational age birth
F Parazzini1, F Chiaffarino, L Chatenoud
1I Clinica Ostetrico Ginecologica, Università di Milano, Milano, Italy. parazzini@marionegri.it
Objective:
We have analysed the association between coffee drinking before and during the three trimesters of pregnancy and risk of small for gestational age (SGA) birth.
Methods:
Cases were 555 women who delivered SGA births (ie <10th percentile according Italian standard). The controls included 1966 women who gave birth at term (>/=37 weeks of gestation) to healthy infants of normal weight.
Results:
In comparison with nondrinkers, the ORs for SGA birth were 1.3 (95% confidence interval, CI, 0.9-1.9) for consumption of four or more cups of coffee/day before pregnancy, and 1.2 (95% CI 0.8-1.8), 1.2 (95% CI 0.8-1.8) and 0.9 (95% CI 0.6-1.4) for consumption of three or more cups of coffee/day during the first, second and third trimester of pregnancy, respectively.
Conclusion:
These findings were consistent in women who delivered preterm and at term births and were not affected by potential confounding such as smoking.
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