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[From qualification to quantification in immunoserological testings].

C Itoh1

  • 1Department of Clinical Pathology, Iwate Medical University, Morioka.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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Quantifications of immunoserological tests like C-reactive protein advanced rapidly in the 1980s. However, significant interlaboratory variations highlight challenges in achieving reliable quantitative performance in immunochemical assays.

Area of Science:

  • Clinical chemistry
  • Immunology
  • Laboratory medicine

Context:

  • The 1980s saw significant advancements in immunoserological testing.
  • Key tests include C-reactive protein (CRP), rheumatoid factor (RF), and antistreptolysin O (ASO).
  • Despite progress, substantial interlaboratory variability was noted.

Purpose:

  • To review the challenges in achieving accurate quantitative results in immunochemical assays.
  • To discuss the difficulties in meeting performance standards for these tests.

Summary:

  • Rapid progress in immunoserological test quantification occurred during the 1980s.
  • Significant interlaboratory differences were observed for tests like CRP, RF, and ASO.
  • The review focuses on the obstacles to obtaining reliable quantitative data.

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Impact:

  • Highlights the persistent challenges in standardization of immunochemical assays.
  • Underscores the need for improved methods to ensure consistent and accurate diagnostic testing.
  • Provides historical context for ongoing efforts in laboratory quality control.