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Updated: Aug 21, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
Published on: June 20, 2015
Pulse-synchronous eye oscillations revealing bone superior canal dehiscence
Caroline Tilikete1, Pierre Krolak-Salmon, Eric Truy
1Neuro-Ophthalmology Department, Hôpital Neurologique, Hospices Civils de Lyon, France. tilikete@lyon.inserm.fr
Abstract:
Superior canal dehiscence syndrome is a newly recognized syndrome characterized by vertigo and nystagmus induced by sound (Tullio phenomenon) or changes of middle ear (Hennebert sign) or intracranial pressure. We report on a patient with bilateral superior canal dehiscence syndrome who presented with unusual manifestations including pulse-synchronous vertical pendular nystagmus and Valsalva-induced, up and counterclockwise-beating jerk nystagmus. These unusual symptoms may be a clue to a better understanding of the pathophysiology of superior canal dehiscence syndrome. Abnormal communication between the inner ears and the intracranial space may explain the vertical pendular and pulse-synchronous nystagmus, modulated by increased intracranial pressure.
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