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[Subcutaneous nodules with malignant presentation, but caused by infection]
S M Hermans1, W E M Schouten, T E Faber
1Universitair Medisch Centrum, Afd. Interne Geneeskunde en Infectieziekten, Postbus 85.500, 350o8 GA Utrecht.
Nederlands Tijdschrift Voor Geneeskunde
|October 1, 2004
Summary
Subcutaneous masses, often suspected as tumors, can be caused by infections like tuberculosis, Bartonella henselae, or Salmonella typhi. Microbiological investigation is crucial for diagnosing these infectious causes of subcutaneous masses.
Area of Science:
- Infectious Diseases
- Oncology
- Dermatology
Background:
- Subcutaneous masses are frequently evaluated for malignancy.
- Infectious etiologies are often overlooked in the differential diagnosis of subcutaneous masses.
- Diagnostic challenges arise due to the varied presentations of subcutaneous masses.
Observation:
- Three patients presented with subcutaneous masses mimicking malignancy.
- Masses were located below the left scapula, inner left upper leg, and near the right eighth rib.
- Diagnostic investigations revealed infections: Mycobacterium tuberculosis, Bartonella henselae, and Salmonella typhi.
Findings:
- Infectious agents were identified as the cause of the subcutaneous masses.
- Antimicrobial therapy proved effective in treating the infections.
- Histopathological examination alone may not suffice for diagnosis.
Implications:
- Microbiological investigation should be considered alongside histopathology for subcutaneous masses.
- Travel history can be a valuable component in diagnosing infectious subcutaneous masses.
- Early and accurate diagnosis through microbiological testing leads to successful treatment and improved patient outcomes.