Related Experiment Video
Updated: Aug 21, 2026

Identification of Mycobacterium Species by DNA Microarray Chip Method
Published on: June 24, 2025
Identification of a familial cluster of pulmonary Mycobacterium bovis disease
P A LoBue1, W Betancourt, L Cowan
1Field Services and Evaluation Branch, Division of Tuberculosis Elimination, Centers for Disease Control, Atlanta, Georgia 30333, USA. pgl5@cdc.gov
Setting:
Local public health department.
Design:
Retrospective review of a cluster of three pulmonary Mycobacterium bovis cases occurring in a family, with genotyping of M. bovis strains isolated from the family members.
Results:
The genotypes of the M. bovis isolates were identical, as determined by three different methods: IS6110 restriction fragment length polymorphism, spoligoytping and mycobacterial interspersed repetitive units-variable number tandem repeat analyses.
Conclusion:
The identification of three acid-fast bacilli (AFB) smear-positive pulmonary M. bovis cases, presenting in a single family and caused by an identical strain, suggests that person-to-person transmission of this organism may have occurred, although infection of one or more family members through ingestion of a contaminated dairy product could not be excluded.
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