Related Experiment Video
Updated: Aug 21, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
Published on: October 2, 2021
Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent
Changhuei Yang1, Laura E L McGuckin, John D Simon
1Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA. chyang@caltech.edu
Abstract:
We report a new molecular contrast optical coherence tomography (MCOCT) implementation that profiles the contrast agent distribution in a sample by measuring the agent's spectral differential absorption. The method, spectra triangulation MCOCT, can effectively suppress contributions from spectrally dependent scatterings from the sample without a priori knowledge of the scattering properties. We demonstrate molecular imaging with this new MCOCT modality by mapping the distribution of indocyanine green, a FDA-approved infrared red dye, within a stage 54 Xenopus laevis.
More Related Videos
06:19In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy
Published on: November 11, 2017
09:56Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time
Published on: November 4, 2014
Related Concept Videos
IR Spectrometers
Infrared (IR) Spectroscopy: Overview
Different compounds display unique properties due to their...