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Factors determining human chorion laeve permeability in vitro
American Journal of Obstetrics and Gynecology
|May 1, 1977
Summary
This study measured drug diffusion across the human chorion laeve. Highly lipid-soluble drugs like meperidine and diazepam showed rapid diffusion, suggesting fast transfer between mother and fetus.
Area of Science:
- Pharmacology
- Physiology
- Biochemistry
Background:
- The human chorion laeve is a key placental barrier.
- Understanding transplacental drug transfer is crucial for fetal safety.
- Factors influencing permeability, such as lipid solubility, are important.