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Effect of BCG vaccine on tuberculin skin tests in 7-11-year-old children

A Bozaykut1, E Atay, H Sevim

  • 1Zeynep Kamil Education and Research Hospital of Maternity and Children's Diseases, Istanbul, Turkey.

Acta Paediatrica (Oslo, Norway : 1992)
|October 1, 2004
PubMed

Insights

Bacillus Calmette Guerin (BCG) vaccination

Area of Science:

  • Pediatrics
  • Immunology
  • Infectious Diseases

Background:

  • Bacillus Calmette Guerin (BCG) vaccination is widely used globally for tuberculosis prevention.
  • The tuberculin skin test (TST) is a common method to assess cell-mediated immunity to Mycobacterium tuberculosis.
  • Understanding BCG's impact on TST responses is crucial for accurate tuberculosis screening.

Purpose of the Study:

  • To evaluate the influence of Bacillus Calmette Guerin (BCG) vaccination on tuberculin skin test (TST) results in children aged 7-11 years.
  • To investigate whether the number of BCG vaccinations and the time elapsed since vaccination affect TST responses.

Main Methods:

  • A study involving 1200 primary school children.
  • Assessment of BCG scar presence and count.
  • Intradermal administration of 5 TU PPD-S.
  • Measurement of PPD induration 72 hours post-test.

Main Results:

  • Mean induration sizes were recorded for children with no scar (3.7 mm), one scar (6.5 mm), and two scars (9.2 mm).
  • No statistically significant difference in mean induration was observed between children with one BCG scar and those with two scars.
  • The study found no significant impact of the number of BCG vaccinations on TST results.

Conclusions:

  • The number of BCG vaccinations and the time interval between vaccination and TST application did not significantly influence TST responses in the studied children.
  • These findings suggest that BCG vaccination history may have a limited, statistically insignificant effect on TST results in this age group.
  • Further research may be needed to fully elucidate the long-term immunological effects of BCG on TST reactivity.
Abstract

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