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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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[Beta-cell, thyroid and celiac autoimmunity in children with type 1 diabetes]

J A López Medina1, R López-Jurado Romero de la Cruz, A Delgado García

  • 1Servicio de Pediatría, Hospital Universitario Virgen de las Nieves, Granada, Spain. jalopezmedina@eresmas.com

Anales De Pediatria (Barcelona, Spain : 2003)
|October 1, 2004
PubMed

Insights

Children with new-onset type 1 diabetes often have co-existing thyroid and coeliac autoimmunity. Early detection and intervention for these conditions are crucial for managing diabetes complications and improving patient outcomes.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Immunology

Background:

  • Type 1 diabetes (T1D) is an autoimmune disease.
  • Autoimmune conditions often coexist in individuals with T1D.
  • Screening for associated autoimmune diseases is important in pediatric T1D.

Purpose of the Study:

  • To assess the prevalence of beta-cell, thyroid, and coeliac autoimmunity in children with recent-onset T1D.
  • To identify potential associations between autoimmune markers and clinical characteristics.

Main Methods:

  • A cohort of 63 children (aged 2-14 years) with newly diagnosed T1D was studied.
  • Antibody testing included GADA, AIA, anti-TPO, anti-TG, TSI, and EmA-IgA.
  • Data on patient demographics and thyroid function were collected.

Main Results:

  • High prevalence of autoantibodies: GADA (65.1%), AIA (68.3%).
  • Thyroid autoimmunity detected in 11.1% (anti-TPO) and 9.5% (anti-TG).
  • Coeliac autoimmunity (EmA-IgA) found in 3.1% of patients. Children with thyroid antibodies were older at diagnosis and had higher rates of thyroid dysfunction.

Conclusions:

  • Newly diagnosed pediatric T1D patients exhibit a significant prevalence of thyroid and coeliac autoimmunity.
  • Routine screening for these autoimmune conditions is recommended.
  • Early detection and management can mitigate complications and improve the clinical course of T1D.
Abstract

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