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Related Experiment Videos

Training-dependent plasticity in patients with multiple sclerosis.

Katrin Morgen1, Nadja Kadom, Lumy Sawaki

  • 1Neuroimmunology Branch, NINDS, National Institutes of Health, Bethesda, MD 20892-1428, USA.

Brain : a Journal of Neurology
|October 1, 2004
PubMed
Summary
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Multiple sclerosis patients show increased motor cortex activation before training. Unlike healthy individuals, they do not optimize brain activation patterns after motor training, suggesting a reduced capacity for motor learning.

Area of Science:

  • Neuroscience
  • Motor Control
  • Neurorehabilitation

Background:

  • Cortical reorganization is observed in the motor network of multiple sclerosis (MS) patients.
  • The impact of motor training on this network's response in MS is not well understood.

Purpose of the Study:

  • To investigate functional MRI (fMRI) activation patterns during a motor task before and after training in MS patients with mild upper extremity impairment.
  • To compare these patterns with those of healthy subjects.

Main Methods:

  • fMRI scans were performed on MS patients and healthy controls before, during, and after a 30-minute motor training session involving voluntary thumb movements.
  • Analysis utilized random effects analysis (SPM99) for fMRI data during rest, trained (flexion), and untrained (extension) movements.

Related Experiment Videos

  • Motor kinematics and electromyography (EMG) were monitored.

    • Main Results:

    • Before training, MS patients exhibited greater activation in the contralateral dorsal premotor cortex (PMd, BA 6) compared to controls.
    • After training, MS patients, unlike controls, did not show task-specific reductions in activation in the contralateral primary somatosensory (S1), motor (M1), and parietal association (BA 40) cortices.

    Conclusions:

    • MS patients utilize the contralateral PMd more than controls for specific movements prior to training.
    • The lack of training-induced activation reduction in S1, M1, and BA 40 suggests a diminished ability in MS patients to optimize motor network recruitment with practice.