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Ras: the other pro-aging pathway.

Valter D Longo1

  • 1Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA. vlongo@usc.edu

Science of Aging Knowledge Environment : SAGE KE
|October 1, 2004
PubMed
Summary
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The Ras pathway, known to regulate longevity in yeast, may also impact aging and stress resistance in mammals. Further research into Ras homologs could reveal new insights into lifespan regulation across eukaryotes.

Area of Science:

  • Cellular and molecular biology
  • Genetics and aging research
  • Eukaryotic longevity pathways

Background:

  • The insulin/insulin-like growth factor-1 (IGF-1)/phosphatidylinositol 3-kinase/Akt pathway is a known regulator of longevity in model organisms like worms, flies, and mice.
  • In yeast, longevity is regulated by a pathway involving Sch9, a homolog of mammalian Akt/protein kinase B.
  • Yeast aging is also influenced by a separate pathway involving Ras, adenylate cyclase, protein kinase A, Msn2/Msn4 transcription factors, and Sod2.

Purpose of the Study:

  • To review experimental data on the role of Ras in regulating stress resistance and lifespan in eukaryotes.
  • To explore the potential role of Ras homologs in mammalian aging, given Ras's function in IGF-1 signaling.

Main Methods:

  • Review of existing studies at both organismal and cellular levels.

Related Experiment Videos

  • Analysis of conserved signaling pathways across different eukaryotic species.
  • Comparative genomics and functional analysis of Ras homologs.

    • Main Results:

    • Evidence suggests a conserved role for Ras in regulating stress resistance and lifespan across eukaryotes.
    • The Ras pathway's involvement in yeast longevity highlights its potential significance in other organisms.
    • Ras proteins, while not previously implicated in worm or fly longevity, play a major role in mammalian IGF-1 signaling.

    Conclusions:

    • Ras proteins are likely involved in the regulation of stress resistance and lifespan in eukaryotes.
    • Homologs of yeast Ras2 may influence aging processes in mammals.
    • Further investigation into the Ras pathway's role in aging is warranted across diverse species.