Etiologic theories of idiopathic scoliosis: neurodevelopmental concepts to be evaluated

There is increasing interest in the concept that neuromuscular mechanisms and the central nervous system (CNS) are somehow involved in the etiology and pathogenesis of idiopathic scoliosis (IS). Yet in the extensive neuroscience research of idiopathic scoliosis certain neurodevelopmental concepts have been neglected. These include: (1) a CNS body schema for posture and movement control generated during development and growth by establishing a long-lasting memory; (2) pruning of cortical synapses at puberty; and (3) neuromorphic engineering. Memory of developing posture and movement might be established in neurons of the CNS body schema in the form of novel proteins; these could be coded by modified genes obtained by the recombination (crossing over) of DNA in a similar way to that in the production of immunological antibodies and during meiosis. These concepts need evaluation in relation to (1) the etiopathogenesis of IS and (2) a possible new treatment approach to idiopathic scoliosis involving a neuromorphic device to control the output for muscle stimulators that are inserted and driven with telemetry.