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Related Experiment Videos

Modified oligosaccharides as potential dental plaque control materials.

Eun-Seong Seo1, Doman Kim, John F Robyt

  • 1Laboratory of Functional Carbohydrate Enzymes and Microbial Genomics, Chonnam National University, Gwang-Ju 500-757, Korea.

Biotechnology Progress
|October 2, 2004
PubMed
Summary

Modified oligosaccharides, specifically iron- and sulfate-oligosaccharides, effectively inhibit glucosyltransferase activity. These compounds reduce oral pathogen growth and acid production, offering a novel approach to preventing dental caries.

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Area of Science:

  • Biochemistry
  • Microbiology
  • Dental Research

Background:

  • Dental caries result from demineralization of tooth surfaces by metabolic acids produced by oral pathogens.
  • Glucosyltransferases (GTFs) are critical enzymes in the pathogenesis of dental caries, facilitating bacterial adhesion and biofilm formation.

Purpose of the Study:

  • To synthesize and evaluate modified oligosaccharides for their inhibitory effects on glucosyltransferase activity.
  • To assess the potential of these modified oligosaccharides in preventing dental caries by targeting key pathogenic mechanisms.

Main Methods:

  • Oligosaccharides were produced via mixed-culture fermentation using Lipomyces starkeyi and Leuconostoc mesenteroides.
  • Synthesized oligosaccharides were further modified into iron- and sulfate-oligosaccharides.

Related Experiment Videos

  • Inhibitory effects on glucosyltransferase activity, biomass formation, oral pathogen growth, and acid production were quantified.

    • Main Results:

    • Iron- and sulfate-oligosaccharides demonstrated significant reduction in glucosyltransferase activity of Streptococci (17%–43%).
    • These modified oligosaccharides prevented insoluble biomass formation on surfaces in the presence of sucrose.
    • Reduced growth and acid production were observed for key oral pathogens, including Streptococcus mutans and Prevotella intermedia.

    Conclusions:

    • Iron- and sulfate-oligosaccharides are potent inhibitors of glucosyltransferase activity and biofilm formation.
    • These compounds show promise in mitigating the virulence of oral pathogens and preventing dental caries development.