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Related Experiment Videos

Controlled ovarian hyperstimulation--an inflammatory state.

Raoul Orvieto1

  • 1Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. orvieto@clalit.org.il

Journal of the Society for Gynecologic Investigation
|October 2, 2004
PubMed
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Controlled ovarian hyperstimulation (COH) can lead to ovarian hyperstimulation syndrome (OHSS). This review explores how COH induces inflammation, potentially via an unknown factor released after human chorionic gonadotropin (hCG) administration.

Area of Science:

  • Reproductive Endocrinology
  • Immunology

Background:

  • Controlled ovarian hyperstimulation (COH) is crucial for in vitro fertilization-embryo transfer success.
  • Severe ovarian hyperstimulation syndrome (OHSS) is a significant complication of COH.
  • OHSS may involve increased inflammatory cytokines or neutrophil activation.

Purpose of the Study:

  • To review the role of COH in initiating an inflammatory response.
  • To investigate the mechanisms underlying OHSS development.

Main Methods:

  • Systematic literature search of studies linking COH and inflammation.
  • Analysis of inflammatory mediator levels following human chorionic gonadotropin (hCG) administration.

Main Results:

  • Increased C-reactive protein, leukocyte, and endothelial selectins post-hCG indicate inflammation and activation.

Related Experiment Videos

  • Human chorionic gonadotropin (hCG) demonstrated a direct inhibitory effect on mononuclear cells in vitro.
  • The indirect mechanism of hCG action is suggested for OHSS development.

    • Conclusions:

    • Human chorionic gonadotropin (hCG) likely triggers an unknown ovarian factor.
    • This intermediate factor may initiate inflammatory processes.
    • These processes could contribute to increased capillary permeability, leading to OHSS.