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Published on: July 30, 2014
Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase
Yanghong Meng1, Hisaaki Takahashi, Jinsong Meng
1Brain and Behavior, The Hospital for Sick Children, Room 6028, McMaster Building, Toronto, Ont. M5G 1X8, Canada.
Abstract:
To investigate the role of the LIM-kinase (LIMK) family in the regulation of ADF/cofilin phosphorylation and synaptic function in the mammalian central nervous system (CNS), we conducted biochemical and electrophysiological analysis using mice that were genetically altered in the expression of LIMK-1 and LIMK-2. We showed here that while LIMK-2 knockout mice exhibited minimal abnormalities, the LIMK-1/2 double knockout mice were more severely impaired in both ADF/cofilin phosphorylation and excitatory synaptic function in the CA1 region of the hippocampus. These results indicate a critical role for the LIMK family in the regulation of ADF/cofilin and synaptic function in the brain.
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