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Updated: Aug 21, 2026

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
Published on: February 7, 2025
Glycomics: a pathway to a class of new and improved therapeutics
Zachary Shriver1, S Raguram, Ram Sasisekharan
1Momenta Pharmaceuticals, 43 Moulton Street, Cambridge, Massachusetts 02138, USA.
Abstract:
Complex glycans that are located at the surface of cells, deposited in the extracellular matrix and attached to soluble signalling molecules have a crucial role in the phenotypic expression of cellular genotypes. However, owing to their structural complexity and some redundancy in terms of structures that elicit a function, the therapeutic potential of complex glycans has not been well exploited, with a few notable exceptions. This review outlines recent advances that promise to increase our ability to use complex glycans as therapeutics. Opportunities for the development of further structure-function relationships for these complex molecules are also discussed.
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