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Thyrotoxic crisis induced by cytotoxic chemotherapy
Khalid A Al-Anazi1, Sohail Inam, M T Jeha
1Section of Adult Haematology and Bone Marrow Transplant, Department of Oncology, King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, 11211, Riyadh, Saudi Arabia. khalid_alanazi@yahoo.com
Summary
Thyroid storm, a rare emergency, occurred in a patient with Graves disease and acute myeloid leukemia during chemotherapy. Prompt management of both conditions led to successful autologous bone marrow transplantation.
Area of Science:
- Endocrinology
- Hematology
- Oncology
Background:
- Thyroid storm is a critical condition.
- Graves' disease is an autoimmune disorder causing hyperthyroidism.
- Acute myeloid leukemia is a cancer of the blood and bone marrow.
Observation:
- A patient with Graves' disease and acute myeloid leukemia developed thyroid storm during chemotherapy.
- Chemotherapy for acute myeloid leukemia can precipitate thyrotoxic crisis in patients with underlying thyroid disorders.
Findings:
- Successful management of both acute myeloid leukemia and thyroid storm was achieved.
- The patient underwent autologous bone marrow transplantation post-treatment.
Implications:
- This case highlights the importance of monitoring thyroid function during chemotherapy in patients with Graves' disease.
- It underscores the need for integrated management of hematologic malignancies and endocrine emergencies.
- Successful outcomes are possible with multidisciplinary care coordination.