[Dynamics of Streptococcos pneumoniae antibiotic resistance extension in Moscow in 1998-2003]

Area of Science:

• Microbiology
• Infectious Diseases
• Pharmacology

Background:

• Antibiotic resistance in Streptococcus pneumoniae is a significant global health concern.
• Understanding local resistance patterns is crucial for effective treatment strategies.

Purpose of the Study:

• To analyze the trends in Streptococcus pneumoniae resistance to various antibiotics in Moscow from 1998 to 2003.
• To investigate the potential correlation between antibiotic usage and resistance emergence.

Main Methods:

• Longitudinal observational study over a 6-year period (1998-2003).
• Monitoring of Streptococcus pneumoniae isolates for antimicrobial resistance.
• Correlation analysis with antibiotic consumption data (inferred).

Main Results:

• A decrease in resistance was observed in 2000-2001, followed by an increase.
• In 2003, resistance rates were 18.6% for penicillin, 19% for erythromycin, and high for tetracycline (40.1%) and co-trimoxazole (29.1%).
• Low resistance rates were noted for amoxicillin (0.4%), cefotaxime (2.1%), levofloxacin, and moxifloxacin.

Conclusions:

• Antibiotic resistance dynamics in Streptococcus pneumoniae are complex and influenced by usage patterns.
• Sustained surveillance and judicious antibiotic use are essential to mitigate rising resistance.
• Fluoroquinolones remained effective against most strains during the study period.