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Related Experiment Videos

[Calcium-dependent programmed cell death in prostate cancer].

Ia M Shuba, N Prevars'ka, R Skryma

    Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994)
    |October 6, 2004
    PubMed
    Summary

    Prostate cancer cells lose apoptosis resistance by altering calcium homeostasis, leading to endoplasmic reticulum calcium depletion. This molecular shift drives advanced, androgen-independent prostate cancer progression.

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    Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells.

    Cell death & disease·2011

    Area of Science:

    • Molecular Biology
    • Cell Biology
    • Oncology

    Context:

    • Prostate cancer is a leading cause of cancer-related mortality in men.
    • Advanced prostate cancer often becomes androgen-independent and resistant to apoptosis.
    • Calcium homeostasis plays a critical role in cellular processes, including apoptosis.

    Purpose:

    • To review the molecular determinants of calcium homeostasis in prostate cancer cells.
    • To elucidate the role of these determinants in the development of apoptosis-resistant phenotypes.
    • To understand the link between calcium dysregulation and advanced prostate cancer.

    Summary:

    • Molecular mechanisms governing calcium homeostasis in prostate cancer cells are detailed.
    • Loss of apoptosis pathway regulation is linked to endoplasmic reticulum calcium store depletion.
    • This endoplasmic reticulum calcium depletion is a hallmark of apoptosis-resistant, advanced androgen-independent prostate cancer.

    Impact:

    • Provides insights into the molecular basis of treatment resistance in prostate cancer.
    • Identifies potential therapeutic targets for overcoming apoptosis resistance.
    • Contributes to a better understanding of prostate cancer progression and therapeutic strategies.

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