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Updated: Aug 21, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
Published on: April 18, 2016
[Dendritic cells, natural killer cells and adhesion molecules in psoriasis]
Min Zhang1, Yi-zhi Zhang, Sheng Wang
1Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To study the role of the dendritic cells, natural killer cells and adhesion molecules play in the pathogenesis of psoriasis.
Methods:
The expression levels of human leukocyte antigen (HLA)-DR, CD1a, CD16, CD57, tumor necrosis factor (TNF)-alpha and intercellular adhesion molecule (ICAM)-1 were detected by immunohistochemistry in lesions of 26 patients with psoriasis before and after treatment.
Results:
The expression of HLA-DR, CD1a, CD16, CD57, TNF-alpha and ICAM-1 showed no significant difference between the active phase and the static phase of psoriatic lesions (P>0.05). After treatment, the positive expression of all markers decreased evidently or even disappeared with histopathological improvement in the resolvent phase of psoriatic lesions. There were statistically significant difference by Wilcoxon rank sum test (P<0.05).
Conclusion:
Dendritic cells, natural killer cells and adhesion molecules play an important role in the pathogenesis of psoriasis.
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