Related Experiment Video
Updated: Aug 21, 2026
A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
Published on: July 25, 2017
[Safety assessment and effect of new-type drinking water on immunity in mice]
Ruixia Song1, Shuxia Xing, Xuetao Bai
1Institute of Environment and Health Related Products Safety, China CDC, Beijing 100021, China.
Objective:
To assess the safety of four kinds new-type drinking water and explore its effect on immunologic function in mice.
Methods:
Its acute oral toxicity and Genotoxicity were detected using acute toxicity test, Ames test, micronucleus assay of mice bone marrow cell and mice sperm malformation test. Its effects on cellular, humoral immune function were assessed respectively by metatarsus-thickening method, Jerne-improved slide method.
Results:
Its acute oral LD50 in mice were greater than 10000mg/kg BW, three genetic toxicity tests showed negative results, the metatarsal injected with SRBC and number of antibody forming cells were no evidently thicker in test group than in control group.
Conclusion:
The result did not indicate the genotoxicity of the four kinds new-type drinking water and they couldn't effect immunologic function in mice.
