[Coagulation changes in inflammatory intestinal disease]

The aim of the present prospective trial was to study the disorders of blood coagulation in 31 patients diagnosed of inflammatory bowel disease (18 with ulcerative colitis and 13 with Crohn's disease) for assessing the possibility of hypercoagulability state in relation to the grade of activity of the disease. During the acute recurrences we observed an increase of factor VIIIC (65.3%), fibrinogen (57.7%), factor VIIIAg (50%), platelet (30.7%) and factor V (19.2%). In two (7.7%) patients a moderate decrease of antithrombin III was detected during a severe episode of activity. During the periods of inactivity the laboratory values concerning the coagulation were normal. There was a correlation between the blood coagulation alterations and the grade of activity of the inflammatory bowel disease.