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Related Experiment Videos

Acute poisoning with emamectin benzoate.

Tzung-Hai Yen1, Ja-Liang Lin

  • 1Division of Clinical Toxicology, Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taipei, Taiwan, Republic of China.

Journal of Toxicology. Clinical Toxicology
|October 7, 2004
PubMed
Summary

Emamectin benzoate insecticide poisoning caused transient gastrointestinal upset, mild CNS depression, and aspiration pneumonia. Treatment involved gastric lavage, activated charcoal, and antibiotics, avoiding GABA-enhancing drugs.

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Area of Science:

  • Agricultural Science
  • Toxicology
  • Neuroscience

Background:

  • Emamectin benzoate, a broad-spectrum insecticide, acts by stimulating GABA receptors, increasing chloride ion permeability.
  • Mammalian safety is attributed to lower GABA receptor affinity and blood-brain barrier impermeability.
  • Human toxicity from emamectin benzoate has not been previously reported in literature.

Observation:

  • A case of acute poisoning from Proclaim insecticide (2.15% emamectin benzoate) is presented.
  • Clinical manifestations included transient gastrointestinal upset, gastric erosion, mild CNS depression, and aspiration pneumonia.
  • Endoscopy confirmed gastric erosion and superficial gastritis.

Findings:

  • No specific antidote for emamectin benzoate intoxication exists.

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  • Successful treatment involved gastric lavage, activated charcoal, and empiric antibiotics.
  • Concurrent use of GABA-enhancing drugs (barbiturates, benzodiazepines) was avoided.

    • Implications:

    • This case highlights potential human health risks associated with emamectin benzoate exposure.
    • Effective management strategies for acute emamectin benzoate poisoning are demonstrated.
    • Further research into human toxicity and safe handling practices is warranted.