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Susac's syndrome or catastrophic antiphospholipid syndrome?

S Bucciarelli1, R Cervera, M Martínez

  • 1Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain.

Lupus
|October 7, 2004
PubMed

Insights

Susac's syndrome, a rare condition, can present similarly to catastrophic antiphospholipid syndrome (APS). This case highlights a patient with Susac's syndrome who also met criteria for probable catastrophic APS.

Area of Science:

  • Neurology
  • Immunology
  • Ophthalmology

Background:

  • Susac's syndrome is a rare microangiopathic disorder affecting the brain, retina, and inner ear.
  • Antiphospholipid syndrome (APS) is an autoimmune disorder increasing blood clot risk.

Observation:

  • A patient presented with rapid-onset encephalopathy, hearing loss, and retinal artery occlusions, characteristic of Susac's syndrome.
  • This patient also tested positive for antiphospholipid antibodies (aPL).

Findings:

  • The patient fulfilled the diagnostic criteria for 'probable' catastrophic antiphospholipid syndrome (APS).
  • This suggests a potential overlap or shared pathogenic mechanisms between Susac's syndrome and APS.

Implications:

  • This case broadens the understanding of Susac's syndrome presentation.
  • It highlights the importance of considering APS in patients with Susac's syndrome features.
  • Further research may elucidate the relationship between these two conditions.

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