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Montelukast in asthmatic patients 6 years-14 years old with an FEV1 > 75%

Allan Becker1, Arlene Swern, Carol A Tozzi

  • 1Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada. becker@Ms.UManitoba.CA

Current Medical Research and Opinion
|October 7, 2004
PubMed
Abstract

Insights

Montelukast significantly improved lung function in children with mild asthma. This leukotriene receptor antagonist demonstrated efficacy in enhancing forced expiratory volume in 1 second (FEV1) and overall quality of life.

Area of Science:

  • Pharmacology
  • Pediatric Pulmonology
  • Clinical Trials

Background:

  • Montelukast is a leukotriene receptor antagonist used for asthma.
  • Asthma management in children requires tailored approaches based on severity.
  • Previous trials established montelukast's efficacy across a range of asthma severities.

Purpose of the Study:

  • To evaluate montelukast's efficacy in a specific pediatric subgroup.
  • To assess montelukast in children aged 6-14 years with milder asthma (FEV1 > 75%).
  • To analyze subgroup data from a broader pediatric asthma clinical trial.

Main Methods:

  • Subgroup analysis of an 8-week randomized, double-blind, placebo-controlled trial.
  • Included pediatric patients (6-14 years) with persistent asthma and FEV1 > 75%.
  • Compared montelukast 5 mg daily to placebo, measuring percentage change in FEV1.

Main Results:

  • Montelukast significantly improved the primary endpoint, percentage change in FEV1, compared to placebo (p=0.005).
  • Other efficacy measures also showed significant improvement with montelukast.
  • Results align with montelukast's established efficacy in broader asthma populations.

Conclusions:

  • Montelukast effectively improves lung function (FEV1) in children with milder persistent asthma.
  • The drug also enhances peak expiratory flow (PEF) and reduces nighttime awakenings.
  • Montelukast positively impacts quality of life in this pediatric subgroup.

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