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Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation
Published on: June 5, 2012
Rats, mice and men - models for immune effector mechanisms against schistosomiasis
1Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM U 167 - CNRS 624, Institut Pasteur, 59019 Lille, France.
Abstract:
Experimental studies have demonstrated the diversity of immune effector mechanisms against schistosomes. Among the various animal models, the rat appears as an excellent experimental system for investigation of antibody-mediated immunity to Schistosoma mansoni. Rat monoclonal antibodies have allowed the identification of effector and regulatory mechanisms operating in human infection, together with the characterization of protective antigens, leading to promising approaches to vaccine development.

