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Updated: Aug 21, 2026

Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)
Published on: April 6, 2019
Trypanothione metabolism: a chemotherapeutic target in trypanosomatids
1Laboratory of Medical Biochemistry, The Rocke feller University, New York, NY 10021, USA.
Abstract:
Chemotherapy of trypanosomotid infections continues to present challenges. Treatment of Trypanosoma cruzi infections is virtually impossible, while treatment of Leishmaniasis and African tryponosomiasis is, at best, difficult - often involving toxic drugs based on heavy metals such as antimony and arsenic. As with several other parasites, much recent research has focused on defining metabolic differences between parasite and host that could represent good targets for chemotherapy. As Graeme Henderson and Alan Fairlamb explain, there is something strange about glutothione in trypanosomotids - which seems to offer a very promising chemotherapeutic target.
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