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Updated: Aug 21, 2026

Extraction of High Molecular Weight Genomic DNA from Soils and Sediments
Published on: November 10, 2009
Molecular weight separation of very large DNA
1Regional Veterinary Laboratory PO Box 388, Benallo, 3672 Victoria, Australia.
Abstract:
Gel electrophoresis has many applications in parasitology, especially for the separation of enzymes, immunoglobulins and DNA, but the ability to separate molecules based on size is usually restricted to within the upper and lower ranges o f molecular weight. These limitations are particularly evident in mocromolecular DNA electrophoresis, although recent innovations in ogorose gel electrophoresis have substantially reduced these boundaries and are permitting the separation of very large DNA molecules and intact chromosomes of many organisms. In this article, Hugh Dawkins explains these techniques and their principle variants.
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