Schistosome proteases

While studies of schistosome antigens have proceeded rapidly over the past ten years, studies of schistosome enzymes have also been increasing apace. Now the two `lines' of research are coming together. Parasites such as schistosomes hardly present antigens merely to stimulate a host immune response, so it is not surprising that many antigens turn out to have functions, for example, as enzymes. One type of antigenic schistosome enzyme - glutathione S-transferase - already shows promise as a vaccine candidate. Here, Jim McKerrow and Mike Doenhoff review another important class of enzyme, many of which are clearly antigenic, the schistosome proteases.