Xenobiotic metabolism in helminths

During its life cycle a parasite, like mammals and other organisms, comes into contact with a variety of toxic molecules. In mammals the main line of defence against such compounds is a group of oxidative enzymes that occur predominantly in the liver. Many of these oxidations are dependent on the haemoprotein cytochrome P-450 which serves as a terminal oxidase accepting electrons from NADPH and cytochrome [Formula: see text] . This review by Wendy Precious and John Barrett illustrates that in contrast to mammals, xenobiotic metabolism in both parasitic and free-living platyhelminths and nematodes is predominantly reductive and hydrolytic as the cytochrome P-450 system is absent. This is surprising since it is present in many groups including bacteria, fungi and protozoa, which suggests an ancient origin. The absence of the cytochrome P-450 system not only severely limits the ability of helminths to detoxify compounds but also limits their ability to activate prodrugs.