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Travellers' malaria.

R Steffen1, R H Behrens

  • 1Division of Epidemiology and Prevention of Communicable Diseases, Institute of Social and Preventive Medicine of the University, Sumatrostrcsse 30, CH-8006 Zürich, Switzerland .

Parasitology Today (Personal Ed.)
|February 1, 1992
PubMed
Summary
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Preventing malaria for travelers is challenging due to widespread drug resistance. Improving personal protection against mosquito bites is a key priority for reducing illness, as current drugs have limitations.

Area of Science:

  • Global Health
  • Infectious Diseases
  • Travel Medicine

Background:

  • Drug resistance in malaria is a growing global concern.
  • Effective malaria prevention for travelers requires knowledge, vector avoidance, and chemoprophylaxis adherence.

Purpose of the Study:

  • To highlight the challenges in malaria prevention for travelers.
  • To emphasize the importance of personal protection against mosquito bites.
  • To review the efficacy and side effects of current malaria chemoprophylaxis drugs.

Main Methods:

  • Review of current literature on malaria risk, drug resistance, and prophylaxis.
  • Analysis of the efficacy and adverse effects of commonly used antimalarial drugs.
  • Discussion of personal protection strategies and self-therapy limitations.

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Main Results:

  • No single antimalarial drug or combination offers 100% efficacy due to increasing Plasmodium falciparum resistance.
  • Commonly used drugs like mefloquine, doxycycline, chloroquine, and proguanil can cause side effects, some severe.
  • Certain drugs are unsuitable for prophylaxis due to adverse reactions, and self-therapy is limited by toxicity and efficacy concerns.

Conclusions:

  • Improving travelers' use of personal protection against mosquito bites is a priority for reducing malaria morbidity.
  • Current chemoprophylaxis options have limitations in efficacy and safety.
  • Careful consideration of risks, benefits, and individual patient factors is essential for malaria prevention in travelers.