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Updated: Aug 21, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

Ivermectin resistance

W L Shoop1

  • 1Merck Research Laboratories, PO Box 2000, Merch and Co., Rahway, NJ 07065, USA.

Parasitology Today (Personal Ed.)
|May 1, 1993
PubMed

Insights

Ivermectin resistance is a growing concern. This review defines resistance, details known cases, and highlights the need for future research into detecting ivermectin resistance, particularly in filariae.

Area of Science:

  • Veterinary Medicine
  • Parasitology
  • Drug Resistance

Background:

  • Ivermectin is a crucial antiparasitic drug.
  • Emerging resistance threatens its efficacy.
  • Understanding resistance mechanisms is vital for continued treatment success.

Purpose of the Study:

  • To review the current understanding of ivermectin resistance.
  • To catalog known instances of ivermectin resistance.
  • To propose future research directions for resistance detection.

Main Methods:

  • Literature review of ivermectin resistance.
  • Analysis of documented cases of resistance.
  • Comparative pharmacology of macrocyclic lactones.

Main Results:

  • Defined ivermectin resistance and its implications.
  • Cataloged all documented cases of ivermectin resistance.
  • Argued for the classification of overmectins and milbemycins in the same action family.
  • Discussed the potential for resistance in filariae.

Conclusions:

  • Ivermectin resistance is a documented phenomenon.
  • Further research is critically needed for the detection of ivermectin resistance.
  • Standardized detection methods will aid in managing resistance.

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