Related Experiment Video
Updated: Aug 6, 2026

A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization
Published on: January 20, 2023
Falsely elevated serum tobramycin levels in a patient receiving nebulised tobramycin
S L Struthers1, T Nicholson, G Jones
1Cystic Fibrosis Team, Department of Paediatrics, Southampton General Hospital, Tremona Rd, Southampton, SO16 6YD, UK. simonstruthers@hotmail.com
Abstract:
It is common when treating patients with respiratory exacerbations of cystic fibrosis to use both nebulised and intravenous antibiotics. Aminoglycoside drug levels are often measured from finger-prick blood samples. We describe a case of a 14-year-old girl treated simultaneously with IV and nebulised tobramycin in whom drug levels, measured from finger prick blood samples, were erroneously high due to finger contamination by the nebulised drug. Special precautions or direct venepuncture is essential when assessing antibiotic levels in such patients.
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