Related Experiment Video
Updated: Aug 21, 2026

08:00
Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
Published on: April 11, 2018
Animal models of cystic fibrosis
Bob J Scholte1, Donald J Davidson, Martina Wilke
1Department of Cell Biology, Erasmus Medical Centre, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. b.scholte@erasmusmc.nl
Abstract:
Animal models of cystic fibrosis, in particular several different mutant mouse strains obtained by homologous recombination, have contributed considerably to our understanding of CF pathology. In this review, we describe and compare the main phenotypic features of these models. Recent and possible future developments in this field are discussed.

