Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein- and gene-based tissue engineering in bone repair.

Michelle D Kofron, Xudong Li, Cato T Laurencin

    Current Opinion in Biotechnology
    |October 7, 2004
    PubMed
    Summary

    Tissue engineering scaffolds using biodegradable polymers combined with bone morphogenetic protein or modified cells promote bone regeneration. These constructs enhance osteogenic differentiation and mineralization for effective bone formation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Nanofiber based transformative approaches for tendon regenerative engineering: past, present and future.

    Nanomedicine (London, England)·2026
    Same author

    Magnesium phosphate functionalized graphene oxide and PLGA composite matrices with enhanced mechanical and osteogenic properties for bone regeneration.

    Regenerative biomaterials·2025
    Same author

    Osteoinductive low-dose 3D porous calcium phosphate graphene oxide-integrated matrices enhance osteogenesis and mechanical properties.

    Proceedings of the National Academy of Sciences of the United States of America·2025
    Same author

    Graphene Oxide in Bone Regenerative Engineering: Current Challenges and Future Perspectives.

    ACS bio & med chem Au·2025
    Same author

    A novel protocol for the direct isolation of a highly pure and regenerative population of satellite stem cells.

    Proceedings of the National Academy of Sciences of the United States of America·2025
    Same author

    Fat Expansion Not Fat Infiltration of Muscle Post Rotator Cuff Tendon Tears of the Shoulder: Regenerative Engineering Implications.

    Regenerative engineering and translational medicine·2025

    Area of Science:

    • Biomaterials Science
    • Regenerative Medicine
    • Orthopedic Research

    Background:

    • Bone regeneration strategies often involve scaffolds, cells, and bioactive factors.
    • Successful tissue-engineered bone grafts mimic autogenic bone's osteoconductivity, osteoinductivity, and osteogenicity.
    • Biodegradable polymers are key components in developing effective bone regeneration scaffolds.

    Purpose of the Study:

    • To investigate the efficacy of tissue-engineered constructs for bone regeneration.
    • To evaluate the potential of poly(lactide-co-glycolide) scaffolds in combination with specific osteogenic agents.
    • To assess the induction of osteogenic differentiation and mineralization in stem cells.

    Main Methods:

    • Utilized biodegradable poly(lactide-co-glycolide) polymer scaffolds.

    Related Experiment Videos

  • Combined scaffolds with bone morphogenetic protein or genetically modified primary cells.
  • Applied constructs in both in vitro and in vivo models.
  • Assessed muscle-derived cells and mesenchymal stem cells for differentiation and mineralization.

    • Main Results:

    • The combination of scaffolds with bone morphogenetic protein or modified cells induced significant osteogenic differentiation.
    • Demonstrated subsequent mineralization by the treated muscle-derived cells and mesenchymal stem cells.
    • Confirmed efficacy in both in vitro and in vivo experimental settings.

    Conclusions:

    • Biodegradable polymer scaffolds combined with specific bioactive factors or modified cells are effective for bone regeneration.
    • These engineered constructs can successfully induce osteogenic differentiation and mineralization.
    • This approach holds promise for advancing treatments in orthopedic repair and tissue engineering.