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Malignant migrating partial seizures in infancy.

Varda Gross-Tsur1, Bruria Ben-Zeev, Ruth S Shalev

  • 1Neuropediatric Unit, Shaare Zedek Medical Center, PO Box 3235, Jerusalem 91031, Israel.

Pediatric Neurology
|October 7, 2004
PubMed
Summary
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Malignant migrating partial seizures in infancy is a rare epileptic encephalopathy. This study adds two cases, highlighting the severe developmental impact and poor prognosis of this condition.

Area of Science:

  • Neurology
  • Pediatric Neurology
  • Epileptology

Background:

  • Malignant migrating partial seizures in infancy (MMPEI) is a rare, severe epileptic encephalopathy.
  • Characterized by early onset (before 6 months), continuous multifocal seizures, and developmental arrest.
  • Often refractory to antiepileptic drugs, with no identifiable cause.

Observation:

  • This report details two new cases of MMPEI.
  • Both infants presented with refractory multifocal seizures and characteristic EEG findings.
  • Neuroimaging revealed progressive cortical and subcortical atrophy.

Findings:

  • One patient remained seizure-free post-infancy but with severe cognitive and motor deficits.
  • The second patient experienced intractable seizures and died at 18 months.

Related Experiment Videos

  • EEG demonstrated shifting ictal activity between hemispheres.

    • Implications:

    • MMPEI represents a devastating, age-specific neurological disorder.
    • Understanding its pathophysiology, potentially involving neurotransmitter dysfunction, is crucial.
    • Further research may lead to novel therapeutic strategies for this rare epilepsy.