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Gonadotrophin dynamics during reproductive life
S F de Medeiros1, P E Assi, M M W Y de Medeiros
1Human Reproductive Unit, Júlio Muller University Hospital, Brazil.
Summary
Follicle-stimulating hormone (FSH) levels non-linearly increase throughout reproductive years. Luteinizing hormone (LH) levels remain stable until age 40, then show a slight increase.
Area of Science:
- Reproductive endocrinology
- Hormonal changes during aging
Background:
- Hormonal fluctuations significantly impact female reproductive health.
- Understanding age-related changes in gonadotropins is crucial for fertility assessments.
Purpose of the Study:
- To analyze follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels during the early follicular phase across reproductive lifespan.
Main Methods:
- Radioimmunoassay (RIA) was used to measure FSH and LH concentrations.
- Statistical analysis involved linear and polynomial regressions, with age as the independent variable.
Main Results:
- Basal FSH levels demonstrated a significant positive correlation with age, increasing non-linearly (r=0.795).
- LH levels remained relatively constant until age 40, after which a modest increase was observed.
Conclusions:
- FSH exhibits a nonlinear rise throughout reproductive life.
- LH shows a discrete increase in women over 40 years of age.