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The Diabetes and Pre-eclampsia Intervention Trial.

V A Holmes1, I S Young, M J A Maresh

  • 1Department of Medicine, Queen's University Belfast, Belfast, UK.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|October 7, 2004
PubMed
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This study investigated if vitamin C and E supplements reduce pre-eclampsia rates in pregnant women with type 1 diabetes. Results will inform nutritional strategies for high-risk pregnancies.

Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Nutritional Science

Background:

  • Type 1 diabetes increases pre-eclampsia risk two to fourfold.
  • Diabetes is linked to oxidative stress and endothelial dysfunction, key factors in pre-eclampsia.
  • Antioxidant depletion and free radical damage are implicated in pre-eclampsia pathogenesis.

Purpose of the Study:

  • To determine if vitamin C and E supplementation lowers pre-eclampsia incidence in type 1 diabetes.
  • To assess the impact of vitamin C and E on endothelial activation markers.
  • To evaluate effects on oxidative stress markers and glycaemic control.

Main Methods:

  • Randomised, double-blind, placebo-controlled trial (DAPIT) of 756 pregnant women with type 1 diabetes.
  • Intervention: Daily vitamin C (1000 mg) and vitamin E (400 IU) versus placebo from 8-22 weeks gestation until delivery.

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  • Primary outcome: Pre-eclampsia. Secondary outcomes: Endothelial activation markers (PAI-1/PAI-2), birthweight centile.

    • Main Results:

    • Data on primary and secondary outcomes are pending completion of the trial.
    • Analysis will compare pre-eclampsia rates between supplemented and placebo groups.
    • Secondary analyses will focus on changes in endothelial markers and oxidative stress.

    Conclusions:

    • The study aims to provide evidence on the efficacy of antioxidant vitamins in preventing pre-eclampsia in type 1 diabetes.
    • Findings may guide clinical recommendations for nutritional support in diabetic pregnancies.
    • Results will contribute to understanding the role of oxidative stress in pre-eclampsia.