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CPP and amlodipine alter the decrease in basal acetylcholine and choline release by audiogenic stimulus in
Turgay Celik1, Hakan Kayir, Mert Ceyhan
1Department of Medical Pharmacology, Psychopharmacology Research Unit, Gülhane Military Medical Academy, Etlik 06018, Ankara, Turkey. tcelik@gata.edu.tr
Brain Research Bulletin
|October 7, 2004
Summary
NMDA receptor and calcium channel antagonists reversed altered acetylcholine release during ethanol withdrawal syndrome (EWS) in rats. This suggests these antagonists may prevent seizures triggered by audiogenic stimuli in EWS.
Area of Science:
- Neuroscience
- Pharmacology
- Addiction Research
Background:
- Ethanol withdrawal syndrome (EWS) is associated with altered neurotransmitter release.
- Hippocampal acetylcholine and choline levels are implicated in withdrawal symptoms and seizure susceptibility.
Purpose of the Study:
- To investigate the effects of NMDA receptor and calcium channel antagonists on acetylcholine and choline release during ethanol withdrawal.
- To determine the role of these pathways in audiogenic stimulus-induced changes during EWS.
Main Methods:
- In vivo microdialysis in Wistar rats administered ethanol via liquid diet for 28 days.
- Administration of NMDA receptor antagonist CPP or calcium channel antagonist amlodipine.
- Application of audiogenic stimulus during ethanol withdrawal.
Main Results:
- Ethanol withdrawal significantly increased basal acetylcholine and choline levels.
- Audiogenic stimulus decreased acetylcholine and increased choline release in ethanol-withdrawn rats.
- CPP and amlodipine administration reversed these altered release patterns.
Conclusions:
- Decreased acetylcholine release post-audiogenic stimulus may contribute to seizure triggering in EWS.
- The hippocampal glutamatergic pathway is involved in audiogenic stimulus-induced acetylcholine release changes during EWS.
- NMDA receptor and calcium channel antagonists may prevent seizures in EWS by inhibiting this pathway.