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Mild acute inflammatory stimulation induces transient negative mood.

Philip C Strike1, Jane Wardle, Andrew Steptoe

  • 1Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK. philip@public-health.ucl.ac.uk

Journal of Psychosomatic Research
|October 7, 2004
PubMed
Summary

Mild inflammation from typhoid vaccination temporarily worsened mood in healthy volunteers. This negative mood shift was linked to chronic financial stress, suggesting stress modulates inflammatory responses.

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Area of Science:

  • Psychoneuroimmunology
  • Inflammation research
  • Mood disorders

Background:

  • Acute inflammatory stimuli can impact psychological states.
  • Understanding the interplay between inflammation and mood is crucial for mental health research.
  • Previous studies have explored the effects of illness on mood, but the impact of mild, induced inflammation requires further investigation.

Purpose of the Study:

  • To investigate mood alterations following mild acute inflammatory stimulation via typhoid vaccination.
  • To examine the relationship between inflammatory responses and psychological well-being.
  • To assess the influence of chronic stressors on mood changes induced by vaccination.

Main Methods:

  • A double-blind, randomized controlled trial involving 26 healthy volunteers.

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  • Participants received either Salmonella typhi vaccine or a placebo injection.
  • Mood, physical symptoms, and body temperature were assessed at multiple time points post-injection using a modified Profile of Mood States.

    • Main Results:

    • Typhoid vaccination did not increase physical symptoms or body temperature.
    • While mood improved in the placebo group, it did not in the vaccine group.
    • Negative mood changes post-vaccination correlated with higher levels of chronic financial strain (r=-.65, P<.025).

    Conclusions:

    • Mild acute inflammation induced by typhoid vaccination can lead to transient negative mood states.
    • Chronic stress, specifically financial strain, modulates the mood response to inflammatory stimuli.
    • Findings suggest implications for understanding depressed mood in the context of physical illness and stress.