Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Surface modification using photocrosslinkable chitosan for improving hemocompatibility.

C Mao¹, J J Zhu, Y F Hu

¹College of Chemistry and Environment Science, Nanjing Normal University, Nanjing 210097, China.

Colloids and Surfaces. B, Biointerfaces

|October 7, 2004

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Interpretation for the health professional standards in appropriate range of body mass index and body weight management for the oldest old].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026

Same author

[Association between blood selenium level and depressive symptoms in older adults aged 65 years and above in 18 longevity areas in China].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026

Same author

[Identification and validation of plasma biomarkers for mild cognitive impairment based on mRNA N<sup>6</sup>-methyladenosine methylome analysis].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026

Same author

[Association between physical activity and non-alcoholic fatty liver disease among adults aged 65 and above in longevity regions of China].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2026

Same author

Overexpression of OsLTSD2 decreases cold tolerance in rice.

Plant biology (Stuttgart, Germany)·2026

Same author

[Association between body composition and high-sensitivity C-reactive protein in older adults aged 65 years and above in 18 longevity areas in China].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2026

Same journal

Drug-loaded nanomicelles with ROS-responsive controlled release of carnosic acid for the treatment of ulcerative colitis.

Colloids and surfaces. B, Biointerfaces·2026

Same journal

Manganese‑containing mesoporous bioactive glass with antioxidative and osteogenic activities for periodontitis treatment.

Colloids and surfaces. B, Biointerfaces·2026

Same journal

Biomimetic PRMT1 inhibitor-loaded manganese-containing bimetallic MOF enhances NSCLC immunotherapy via cGAS-STING activation and PD-L1 blockade.

Colloids and surfaces. B, Biointerfaces·2026

Same journal

Interfacial engineering in lipase-catalyzed synthesis of functional lipids: Mechanisms, strategies, and prospects.

Colloids and surfaces. B, Biointerfaces·2026

Same journal

Electroactive collagen nanofibrous scaffolds stabilized with polyphenols, dopamine, and reduced graphene oxide for infection-resistant bone regeneration.

Colloids and surfaces. B, Biointerfaces·2026

Same journal

Unmodified orientable osteoclastic cytomembrane bionic fluorescent magnetic nanocarbons as high-efficiency multifunctional platforms for antiresorptive compound discovery.

Colloids and surfaces. B, Biointerfaces·2026

See all related articles

Researchers developed a new method to coat glass surfaces with O-butyrylchitosan (OBCS) for improved blood compatibility. This anticoagulative coating significantly reduced platelet adhesion and fibrinogen adsorption, showing promise for artificial biomaterials.

Area of Science:

Biomaterials Science
Surface Chemistry
Biomedical Engineering

Background:

Improving blood compatibility of artificial biomaterials is crucial.
Immobilizing anticoagulative biomolecules is a key strategy.
Current methods require novel immobilization techniques.

Purpose of the Study:

To develop a novel anticoagulative glass substrate.
To immobilize O-butyrylchitosan (OBCS) onto a glass surface.
To evaluate the blood compatibility of the modified surface.

Main Methods:

Glass surface activation via silanization.
O-butyrylchitosan (OBCS) grafting using radiation.
Surface characterization using ESCA and AFM.
In vitro blood compatibility testing with PRP and protein adsorption.

Related Experiment Videos

Main Results:

Successful immobilization of OBCS onto activated glass.
OBCS-grafted surfaces showed significantly reduced platelet adhesion.
Fibrinogen adsorption was markedly lower on OBCS-grafted surfaces compared to controls.

Conclusions:

The novel immobilization scheme is effective for creating anticoagulative surfaces.
OBCS-grafted glass demonstrates enhanced blood compatibility.
This approach holds significant potential for developing improved artificial biomaterials.